Known

He was a known pickpocket.

Being not knowne, some great persons in the pew I pretended to, and went in, did question my coming in.

At the time, Einstein's theory was unknown to most other scientists.

As we age, the major arteries of our bodies frequently become thickened with plaque, a fatty material with an oatmeal-like consistency that builds up along the inner lining of blood vessels. The reason plaque forms isn’t entirely known, but it seems to be related to high levels of cholesterol inducing an inflammatory response, which can also attract and trap more cellular debris over time.

You have to tell the knowns from the unknowns.

The biological dereplication tool may identify major knowns in a mixture, but it may miss novel minor components.