Underdose

“[…] I put laudanum in his coffee last night. I was afraid to put in too much for fear of killing him, so I suppose I didn’t put in enough, for he laid wide awake all night.” “Ah, yes! that would be the effect of an under-dose of laudanum.”

If Patrick were to add a little sugar to her urine specimen so that she would take a hefty dose of insulin, and then to make her take a good walk without her little tin of glucose […] she would probably pass out on the mountainside. Or suppose he substituted his own urine in the test tube so that she would take an under-dose?

“Seems as though sometimes I get an overdose of feeling, and an underdose of sense.”

It seems the kid suffers from an underdose of mother love, so he kills pretty girls—exactly the problem of Norman Bates in Alfred Hitchcock’s “Psycho.”

1945, Alexander Fleming, Nobel acceptance speech, cited in Jenny Rohn, “The hunt is on for new antibiotics—but we have to start looking outside the lab,” The Guardian, 19 February, 2015, The time may come when penicillin can be bought by anyone in the shops. Then there is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant.

2016, Kelly Close, letter to the editor, The New York Times, 29 February, 2016, It is true that insulin costs are high; as a result some patients may underdose. We need better reimbursement to address that.

[…] a Child new-born may take an eighth or tenth part of a paper, a Child of a year old a quarter of a paper or a sixth part, 2, 3, or 4 years old a third 5, 6, 7, half a paper, &c. for you cannot hurt if you over or under dose it a little; the Medicine being safe.

An intern underdosed her heparin (blood thinner), and she suffered a large blood clot in a lung.