Parasympatheticolytic

Drugs used were hydergine, a sympatheticolytic and vasodilator combination of dihydroergocornine, dihydroergocristine and dihydroergokryptine, and bellergal, a combination of a parasympatheticolytic bellafoline, a sympatheticolytic ergotamine tartrate and a sedative phenobarbitone.

It is our interpretation that this is probably due to a parasympatheticolytic effect of alcohol.

There is an occasionally important depression, and considerable drowsiness, and a parasympatheticolytic effect apparently relative to norepinephrine depletion.

Also, one cannot get the full effect without other systemic symptoms ranging from tachycardia for the sympatheticomimetics to dryness of the mouth in the case of the parasympatheticolytics.

Thus, it has been eventually possible, as well, to direct and give ground to their therapy and prophylaxis, decreasing vagal hyperreflexia by means of parasympatheticolytics; to decrease the duration and effect of cerebral anoxias by means of the Trendelemburg^([sic]) position; to eliminate stimulating cardio-inhibitory vagal reflexogenic factors: intestinal parasites, suppositories, enemas, nasal or auricular instillations; to correct inadecuate^([sic]) psychological stimuli in hypervagotonic children by means of psychopedagogy and psychotherapy.

Flemming (1954) found, after instillation of drugs into the conjunctival sac, that sympathetico-memetics and parasympatheticolytics increase the flicker frequency, while parasympathetico-memetics and sympatheticolytics reduce it. (Alpern and Jampel, 1959).

The reported clinical “successes” of treatment with carbamylcholine (a parasympathomimetic) and hyoscine (a parasympatheticolytic similar to atropine) that have opposite activities cannot be easily reconciled.

Dilation of the pupil is usually required prior to intraocular surgery. A combination of a topical sympathomimetic, such as phenylephrine, and a parasympatheticolytic such as cyclopentolate, atropine or others, is often used.