Parasympathicolytic

The parasympathicolytic action of camphor on the vagus is localised in the postganglionic fibres and is comparable with the action of atropine.

TK is not a central parasympathicolytic antiparkinson agent; moreover, it has no central nervous effect and no parasympathicolytic action in isolated organs.

TL 301 possesses parasympathicolytic action, slowly blocking vagal inhibition of the heart in the anesthetized rabbit in doses of 20 to 30 mg kg given intravenously.

Because of this activity, which occurs regardless of the innervation, the spasmolytic action is not accompanied by the side effects, due to stimulation or inhibition of other organs, which are regularly observed in the case of parasympathicolytics, sympathicomimetics, etc.

Muscarinic side effects such as salivation, abdominal cramps and diarrhoea can be counteracted with parasympathicolytics.

Prior to examination of the comatose patient, make sure that all vital functions are secured according to the ABC approach. Then start with an external inspection and look for trauma (e.g., revealed by retroauricular and periorbital subcutaneous hemorrhages) and signs of intoxication (e.g., cherry-red skin coloration such as in carbon monoxide poisoning; mydriasis with sympathicomimetics, e.g., cocaine; or parasympathicolytics, e.g., atropine; miosis with opioids) or drug abuse (e.g., injection sites).